If you've spent any time scrolling through skincare TikTok or browsing the latest K-beauty launches, chances are you've come across PDRN. It's one of the buzziest skincare ingredients right now, appearing in everything from serums and moisturisers to eye creams and sheet masks, with products promising plumper, firmer, glowier skin. But whilst PDRN might feel like a recent discovery, it has actually been used in medical and aesthetic treatments for years. And, like so many skincare ingredients that suddenly find themselves at the centre of a viral trend, there's a little more to it than the marketing might have you believe.

PDRN stands for polydeoxyribonucleotide, a purified fragment of DNA traditionally sourced from salmon or trout. It's best known for its use in professional aesthetic treatments, where it's associated with skin repair, collagen support and improvements in overall skin quality. In recent years, the ingredient has moved beyond the treatment room and into topical skincare, with brands developing formulas designed to deliver some of these benefits at home. There's even a growing market for vegan PDRN, which uses plant-derived or biotechnology-produced alternatives.

The excitement surrounding PDRN isn't entirely unfounded. According to Alicia Gonzalez-Fernandez, a London-based aesthetic and NHS doctor, it has become a popular ingredient in injectable treatments, particularly for the delicate under-eye area. "The main benefit is better skin quality," she explains. "Skin feels more hydrated, texture becomes smoother, and it gradually gains firmness and elasticity as collagen production improves. It also supports the skin barrier, so reactive or red skin tends to become calmer," she adds. However, the evidence supporting injectable treatments is not necessarily transferable to the serums and creams now lining our bathroom shelves.

(Image credit: @cassklatzkow)

This is where things get interesting. PDRN is a relatively large molecule, which presents a challenge when it comes to topical delivery. As Gonzalez-Fernandez explains, "When you apply it to the surface of the skin, only a small amount gets past the skin barrier." Meanwhile, skincare brands are investing in new technologies and delivery systems in an attempt to make topical formulations more effective.

So, does a PDRN serum actually work? Is fish-derived PDRN more effective than vegan alternatives? And how do topical products compare with in-salon treatments? To separate the science from the skincare hype, I also spoke to Daniel Isaacs, brand founder and chief product officer at Medik8, along with Gonzalez-Fernandez, to find out what PDRN is, what it can realistically do for your skin, and whether it's an ingredient worth adding to your skincare routine.

What Is PDRN?

PDRN was originally developed for medical applications involving wound healing and tissue repair, before becoming increasingly popular in aesthetic medicine. Gonzalez-Fernandez explains that, in the skin, PDRN "works as a repair signal", supporting processes associated with collagen production, inflammation and cellular regeneration. It may also help with uneven tone and pigmentation by influencing melanin production. The overall aim is to improve skin quality rather than change facial structure or volume in the way some injectable treatments can.

Isaacs describes PDRN as "a DNA-based ingredient known for its role in supporting skin recovery and rejuvenation". He explains that its growing popularity in professional treatments has encouraged brands to explore how it might be incorporated into topical formulas. "At Medik8, we've developed a pioneering vegan form of PDRN designed to support the skin's natural processes and promote a healthier, more youthful-looking complexion," he says.

It's worth remembering that PDRN is now used quite broadly in skincare marketing. Products can differ in their source, concentration, formulation and delivery technology, so seeing the ingredient on a label doesn't automatically mean a serum will produce the same effects as an injectable treatment.

Does PDRN Skincare Work?

The short answer is that topical PDRN shows promise, but the evidence is still developing. It's important to distinguish between the research supporting injectable PDRN and polynucleotide treatments and the more limited evidence available for applying these ingredients to the skin's surface. Gonzalez-Fernandez explains that PDRN is a large molecule, meaning "only a small amount gets past the skin barrier" when used topically.

Isaacs believes formulation technology can help address this challenge. "One of the biggest challenges with traditional PDRN is its molecular size, which can limit how effectively it penetrates the skin when applied topically," he explains. "That's why we developed our prismatic PDRN with a stable, three-dimensional structure designed to optimise absorption." He adds, "It's not simply about including an innovative ingredient, but engineering it to work effectively within a skincare formula."

For a realistic assessment of a PDRN serum, Gonzalez-Fernandez recommends using it consistently for at least three months, provided your skin tolerates it. Ultimately, the overall formula matters, and topical PDRN shouldn't be treated as a guaranteed shortcut to firmer, more youthful-looking skin. If you're thinking of adding one to your routine, I've tested plenty of popular PDRN serums and rounded up my top picks below.

Shop the Best PDRN Serums

  • Best Overall PDRN Serum: Medik8 Exo-PDRN Prismatic+, £79
  • Best Vegan PDRN Serum: The Inkey List Inkey Lab PDRN Serum, £18
  • Best Glowy PDRN Serum: Anua PDRN Hyaluronic Acid Capsule 100 Serum, £22
  • Best High-Strength PDRN Serum: Medicube Pink Peptide Serum, £18
  • Best Multitasking PDRN Serum: Byoma Longevit-8 Peptide Serum, £22
1. Medik8 Exo-PDRN Prismatic+ Serum

Best Overall

Medik8 Exo-PDRN Prismatic+ Serum

Key ingredients: Vegan prismatic PDRN, niacinamide, centella asiatica, triple exosome complex, GF MiniProtein, hyaluronic acid

Pros

  • Vegan Society-certified and fragrance-free.
  • Combines PDRN with peptides, niacinamide, and hydrating ingredients.
  • Lightweight, water-based texture designed to layer easily.

Cons

  • One of the most expensive options in this edit.
  • PDRN concentration isn't publicly disclosed.

(Image credit: @thatgracegirl)

Why we love it: This vegan formula goes beyond PDRN, combining it with exosomes, peptides and niacinamide to target everything from dullness to uneven tone. It’s a sophisticated, multitasking option which quickly delivers noticeable results.

Facialist review: This genuinely effective serum was one of the most impressive that I tried when it came to delivering results. I felt like my skin appeared much brighter and healthier within just a few weeks of use. I particularly like that the formula also includes niacinamide, centella asiatica and sodium hyaluronate, bringing some familiar favourite and hydrating ingredients into the mix so that you don't need to layer multiple serums together. According to Isaacs, this allows the serum "to deliver a more comprehensive approach to visible rejuvenation, targeting everything from luminosity and uneven tone to fine lines and firmness."

2. The Inkey List Inkey Lab PDRN Serum

Best Vegan PDRN

The Inkey List Inkey Lab PDRN Serum

Key ingredients: Vegan INJIN PDRN, glycerin, shea butter, sunflower seed oil, vitamin E

Pros

  • Clearly advertises its PDRN concentration.
  • Vegan, fragrance-free, and relatively affordable.
  • Glowy, softening effect and non-greasy feel.

Cons

  • The richer emollient blend may not suit those who prefer a very lightweight serum.
  • The high advertised concentration isn't directly comparable with products using non-vegan PDRN.

(Image credit: @thatgracegirl)

Why we love it: The Inkey List is known for offering accessible ways to try skincare trends—this affordable vegan formula pairs plant-derived PDRN with moisturising ingredients to leave skin feeling softer, smoother and more supple.

Facialist review: This affordable option utilises 20,000 ppm (2%) vegan PDRN, derived from the herb Artemisia capillaris, alongside an 18% emollient blend designed to give skin a smooth, glass-like glow. Glycerin adds hydration, while the formula's cushioning texture makes it feel more nourishing than a typical hydrating gel serum. I immediately noticed softer, bouncier skin and a lasting glow, and loved that it absorbed quickly without leaving a greasy residue (despite the richer ingredients).

3. Anua PDRN Hyaluronic Acid Capsule 100 Serum

Best Glowy PDRN

Anua PDRN Hyaluronic Acid Capsule 100 Serum

Key ingredients: Salmon-derived PDRN, multiple forms of hyaluronic acid, niacinamide, hydrolysed collagen, glutathione

Pros

  • Multiple humectants help boost surface hydration.
  • Lightweight, dewy finish.
  • Strong customer reviews.

Cons

  • The brand doesn't disclose a clear PDRN concentration in the product information.
  • The dewy finish may not appeal to those who prefer a matte complexion.

(Image credit: @thatgracegirl)

Why we love it: If glow is your priority, this lightweight K-beauty serum combines salmon-derived PDRN with hyaluronic acid for a dewy-looking finish. It’s a great option for anyone who loves that fresh, glass-skin glow.

Facialist review: In classic K-beauty fashion, this one is all about hydration and glow. Its capsule-serum formula combines salmon-derived PDRN with multiple forms of hyaluronic acid, collagen and niacinamide to help skin look plumper, smoother and more radiant. The lightweight texture absorbs quickly (ideal if, like me, you love a dewy finish) and layers well under other products. If your main goal is hydrated, bouncy-looking skin rather than a high PDRN concentration, this is a strong contender—and rave user reviews agree.

4. Medicube PDRN Pink Peptide Serum

Best High-Strength PDRN

Medicube PDRN Pink Peptide Serum

Key ingredients: Salmon-derived PDRN, niacinamide, glycerin, five-type peptide complex, hydrolysed collagen

Why we love it: With a stated 1% PDRN concentration alongside peptides and niacinamide, this formula is designed to target multiple signs of dull, tired-looking skin.

Facialist review: This is one of the more recognisable products in the K-beauty PDRN boom—the pink bottle is all over my TikTok feed. Pairing salmon-derived DNA with niacinamide and a multi-peptide complex, as well as glycerin and other humectants to support hydration, it's a great multitasker. It earns its place here for having the highest non-vegan PDRN concentration on the list—10,000 ppm/1%.

Pros

  • Clearly advertised 1% PDRN concentration.
  • Combines PDRN with peptides and hydrating ingredients.

Cons

  • Contains fragrance.
  • Not vegan—avoid if you have a fish allergy.
  • A little sticky in texture.
5. Byoma Longevit-8 Peptide Serum

Best Multitasking PDRN

Byoma Longevit-8 Peptide Serum

Key ingredients: Vegan phyto-PDRN, copper tripeptide-1, niacinamide, NMN, ceramide NP, vitamin E

Pros

  • Relatively affordable price point.
  • Combines peptides, barrier-supporting lipids and PDRN in one formula.
  • Lightweight and designed for easy layering.
  • Fragrance-free and marketed for all skin types, including sensitive skin.

Cons

  • PDRN concentration isn't disclosed.
  • The number of active ingredients may make it harder to identify which ingredient is responsible for any changes.

(Image credit: @thatgracegirl)

Why we love it: This formula brings together a cocktail of proven ingredients in one easy step. It’s a smart choice if you want to support your skin barrier whilst also targeting the look of fine lines and loss of radiance.

Facialist review: This multitasking formula looks beyond PDRN alone, combining vegan phyto-PDRN with peptides, niacinamide, NMN and a ceramide complex. The idea is to support several aspects of skin health in one step, from hydration and barrier function to the appearance of fine lines, firmness and luminosity. Copper tripeptide-1 and other peptides make this particularly beneficial for those drawn to the trend for "skin longevity", whilst ceramide NP, cholesterol and fatty acids help support the skin barrier (always a plus). I find that the lightweight texture layers easily with the rest of my routine and doesn't cause any issues for my sensitive skin.

6. Haruharu Wonder Rose PDRN Soothing Serum

Best PDRN Serum for Sensitive Skin

Haruharu Wonder Rose PDRN Soothing Serum

Key ingredients: Vegan rose PDRN, azelaic acid, niacinamide, panthenol, beta-glucan, centella asiatica, squalane

Pros

  • Vegan PDRN from Damask rose.
  • Includes ingredients that target redness, uneven tone, and hydration.
  • Lightweight feel and soothing effect.

Cons

  • PDRN concentration isn't disclosed.
  • Evidence for vegan PDRN itself remains limited compared with established topical actives.

(Image credit: @thatgracegirl)

Why we love it: This serum has a soothing, skin-comfort-focused approach. We love that it also includes azelaic acid and niacinamide to help address uneven tone.

Facialist review: If you want to explore PDRN but prefer a formula with a soothing, skin-comfort focus, look no further. This one is powered by vegan PDRN derived from Damask rose alongside azelaic acid, niacinamide, panthenol, beta-glucan and centella asiatica to target hydration, visible redness and uneven texture. I find it absorbs quickly, feels immediately soothing and delivers improvements in redness. The combination of azelaic acid and niacinamide is one of my favourites for those dealing with post-acne pigmentation or uneven tone, and gives this formula more of a targeted focus compared to others I tried.

7. No7 Good Intent Dew Bank Water Serum with PDRN

Best Hydrating PDRN Serum

No7 Good Intent Dew Bank Water Serum with PDRN

Key ingredients: PDRN, hyaluronic acid, niacinamide, panthenol, ginseng root water, peptides, glycerin

Pros

  • Hydration-focused formula with multiple skin-conditioning ingredients.
  • Lightweight, fluid texture designed for a dewy finish.
  • Affordable price point.

Cons

  • PDRN source and concentration aren't publicly specified in the information reviewed.
  • Those seeking a true PDRN serum should look for one with a clearly stated PDRN strength.

(Image credit: @thatgracegirl)

Why we love it: This lightweight, water-based serum focuses on hydration, pairing PDRN with ingredients such as hyaluronic acid, glycerin and panthenol. It’s a lovely option if you want a fresh, dewy finish without adding a heavy layer to your skincare routine.

Facialist review: This serum takes a hydration-first approach, with a lightweight formula featuring oil-encapsulated bubbles suspended in a cushiony, water-based serum. And yes, it feels every bit as good as it sounds. Glycerin, hyaluronic acid and panthenol help attract and retain moisture, while niacinamide supports the skin barrier and helps improve the appearance of uneven tone. It's basically glass skin in a bottle, and a perfect antidote to parched, dehydrated skin. No7 doesn't clearly disclose the PDRN concentration or its source, so I would view this more as a hydrating treatment than a true PDRN serum.

8. Biodance Caviar PDRN Jelly Serum Mist

Best Spray-On Serum

Biodance Caviar PDRN Jelly Serum Mist

Key ingredients: Salmon-derived PDRN (sodium DNA), caviar extract, glycerin, niacinamide, multiple forms of hyaluronic acid

Pros

  • Convenient spray format for use throughout the day.
  • Combines PDRN with humectants for a hydrated, dewy finish.
  • Refreshing and soothing application.

Cons

  • A mist may not provide enough lasting moisture on its own for very dry skin.
  • Fish-derived ingredients mean it's not suitable for a vegan routine.

(Image credit: @thatgracegirl)

Why we love it: This convenient (and cute!) mist makes topping up hydration throughout the day feel effortless, with PDRN, caviar extract and humectants to help skin look fresh and radiant. We love it as a fuss-free way to add a little extra dew to your routine, particularly when skin is feeling parched.

Facialist review:

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